Cooperative Intermolecular Interactions Regulate Supramolecular Polymer Assembly

Biological supramolecular structures exhibit both lateral and longitudinal interactions, rendering the structure responsive to changes. Thus far, lateral interactions of synthetically assembled supramolecular polymers have only been elucidated. Inspired by microtubules, this study reports cooperative self-assembly of aryl barbiturate molecules into helical coils, driven by the concerted action of noncovalent lateral and longitudinal interactions. These synthetic polymers uniquely alter with changes in temperature. This conceptual advancement will influence future material designs of next-generation polymers.